A Drosophila NSF mutant

Drosophila melanogaster mutant

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Hexaptera, a Homoeotic Mutant in Drosophila Melanogaster.

Nsf.

Genome-wide association studies (GWAS) facilitate largescale identification of genomic variants that are associated with complex traits. However, susceptibility loci identified by GWAS so far generally account for a limited fraction of the genotypic variation in patient populations. Predictive models based on identified loci also have modest success in risk assessment and therefore are of limit...

Genetic modifiers of the Drosophila NSF mutant, comatose, include a temperature-sensitive paralytic allele of the calcium channel alpha1-subunit gene, cacophony.

The N-ethylmaleimide-sensitive fusion protein (NSF) has been implicated in vesicle trafficking in perhaps all eukaryotic cells. The Drosophila comatose (comt) gene encodes an NSF homolog, dNSF1. Our previous work with temperature-sensitive (TS) paralytic alleles of comt has revealed a function for dNSF1 at synapses, where it appears to prime synaptic vesicles for neurotransmitter release. To fu...

A neuroprotective function of NSF 1 sustains autophagy and lysosomal trafficking in Drosophila Daniel